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KMID : 1140120110160010080
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Cancer Prevention Research
2011 Volume.16 No. 1 p.80 ~ p.85
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Anthocyanins Isolated from Vitis coignetiae Pulliat Suppress NF-κB-regulated Genes Involved in Cell proliferation, Anti-apoptosis, Invasion and Angiogenesis
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Kim Min-Jeong
Lee Won-Sup
Lu Jin-Nan
Yun Jeong-Won
Chang Seung-Hwan
Choi Yung-Hyun
Jung Jin-Myung
Ryu Chung-Ho
Park Ock-Jin
Hong Soon-Chan
Shin Sung-Chul
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Abstract
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NF-κB activation is closed related to the cancer cell proliferation, invasion, angiogenesis, metastasis, and drug resistance. We previously suggested that anthocyanins from fruits of Vitis coignetiae Pulliat (AIMs), which had been used as a remedy for inflammatory diseases and cancers, should have anti-cancer properties. We tried to validate their effects on NF-κB-regulated gene products in Hep3B human hepatoma cells. The AIMs inhibited the cell proliferation of Hep3B cells in a dose-dependent manner. To clearly demonstrate their effects, we used TNF-α which is an activator of NF-κB. AIMs suppressed the NF-κB-regulated proteins (Cyclin D1, COX-2, C-myc, Bcl-2, Bcl-xL, XIAP, cIAP1, cIAP2, MMP-2, MMP-9, ICAM, and VEGF) induced by TNF-α. In summary, this study indicates that the AIMs have inhibitory effects on NF-κB downstream proteins involved in cell proliferation, anti-apoptosis, cell invasion, and angiogenesis. This study provides the evidence that the anthocyanins isolated from Vitis coignetiae Pulliat might be useful in the treatment of human hepatocellular carcinoma.
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KEYWORD
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Anthocyanin, IMs, Hep3B, TNF-α, NF-κB
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